Precision Weight Loss
Semaglutide (injection)
A once-weekly injection you give yourself at home, compounded to the dose your clinician sets.
Browse freely. To purchase medication, you’ll enroll in membership and complete a clinician review. Medication is charged separately and is prescribed only when clinically appropriate.
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Check another state or optionMeet Semaglutide (injection)
How it works
A GLP-1 receptor agonist. It mimics a gut hormone released after eating, which slows how fast the stomach empties, signals fullness to the brain, and prompts insulin release when blood sugar is high. Appetite falls because the signal that says 'enough' arrives earlier and lasts longer.
What to expect
Weight change is gradual and begins during titration rather than after it. Nausea, fullness, constipation or reflux are common in the first weeks and usually settle as the dose stabilises; they are the main reason people stop. Appetite suppression is often noticed before any change on the scale.
From your clinician’s notes
Semaglutide is a GLP-1 receptor agonist. It is given as a small injection just under the skin, once a week, into the abdomen, thigh, or upper arm. The needle is short and fine, and most people are done in under a minute. Your dose starts low and steps up over time. Your clinician sets that schedule from your intake, your labs, and how you actually respond — you are not put on a fixed ladder and left there. Included with your $149 monthly membership: your starter lab panel, one-on-one health coaching, 24/7 clinician access, and the member portal where your dose, refills, and shipments live. Billed separately: the medication itself, monthly, plus shipping. You are not charged for medication until a clinician has approved it and the pharmacy has accepted the order — both, in that order. This is a compounded preparation dispensed by a licensed 503A pharmacy. It is not a manufactured brand-name product, and the two are not interchangeable. It requires a prescription. Completing an application does not mean semaglutide will be prescribed: some people are not appropriate candidates, and your clinician will tell you plainly if that is the case.
Uses and regulatory status
Chronic weight management alongside a change in diet and physical activity, in adults who meet the clinical criteria. It is not a short course and it is not a substitute for the rest of the plan.
Semaglutide is FDA-approved for chronic weight management. The preparation dispensed here is compounded by a licensed 503A pharmacy and is NOT an FDA-approved finished product; compounded preparations are not reviewed by the FDA for safety, effectiveness or manufacturing quality.
Chronic weight management is an FDA-approved indication for this active ingredient. The indication is approved; this compounded formulation is not itself an approved product.
Safety & monitoring
Important safety information
Contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, and in pregnancy. Serious but uncommon risks include pancreatitis, gallbladder disease, and worsening of diabetic retinopathy. Rapid weight loss without adequate protein and resistance training costs lean mass.
Monitoring
Weight and waist at each check-in, blood pressure, and metabolic labs including HbA1c and lipids. Muscle mass matters as much as total weight, which is what the monthly coaching call is for. Any severe or persistent abdominal pain is reported the same day.
About this form
Administration, storage, evidence limits, formulation
- Administration
- One subcutaneous injection a week, on the same day each week, into the abdomen, thigh or upper arm. Rotate the site each time. Draw the volume your clinician specifies for your current step — at 5 mg/mL the maintenance 2.4 mg dose is 0.48 mL. Use a new needle every time and dispose of it in a sharps container, never a household bin. If you miss a dose and the next one is more than two days away, take it when you remember; otherwise skip it. Never double up.
- Storage
- Refrigerate at 2-8 degrees C. Do not freeze; a preparation that has frozen is discarded, not thawed. Keep the vial in its carton, away from light. Once punctured, use within the beyond-use date the pharmacy prints on the label — that date, not the manufacturer shelf life you may read elsewhere. It can sit at room temperature briefly for travel; ask before relying on that.
- Evidence limits
- The trials behind semaglutide studied the FDA-approved product at defined doses. This is a compounded preparation containing added glycine and cyanocobalamin, and no clinical trial has tested it. Its behaviour is inferred from the approved product rather than demonstrated. Nobody can tell you it performs identically, and nobody has measured whether it does.
- Formulation
- Prepared by a licensed 503A compounding pharmacy (Strive) with added ingredients; not the FDA-approved finished product.
Compounded by a licensed 503A pharmacy. This is NOT an FDA-approved finished product: compounded preparations are not reviewed by the FDA for safety, effectiveness or manufacturing quality, and it is not interchangeable with the brand-name product. It also contains added ingredients not present in the approved formulation.
Medication guide
Discovery and background
The GLP-1 story starts with a lizard. In the 1990s a peptide in Gila monster venom, exendin-4, was found to resemble human GLP-1 but to survive far longer in the body — human GLP-1 is broken down within minutes, which had made it useless as a drug. That became exenatide, then liraglutide, then semaglutide, each engineered to last longer. Weight loss was noticed as a side effect in diabetes trials before it was ever the goal.
Evidence
The STEP programme tested semaglutide 2.4 mg weekly for weight management. STEP 1 (NEJM 2021) randomised 1,961 adults without diabetes and reported substantially greater weight reduction than placebo over 68 weeks, alongside improvements in waist circumference, blood pressure and lipids. Discontinuation for gastrointestinal side effects was higher than placebo. IMPORTANT LIMIT: those trials studied the FDA-approved product, not a compounded preparation. No trial has tested what is dispensed here.
Risks
Gastrointestinal effects are common and dose-related. Pancreatitis is uncommon but the reason new severe abdominal pain is treated as urgent. Gallstones become more likely with rapid weight loss. Retinopathy can worsen in people with pre-existing diabetic eye disease when glucose falls quickly. Lean mass loss is real and under-discussed: without deliberate protein intake and resistance training a meaningful share of weight lost is muscle. Weight regain after stopping is common and well documented, which is why the plan should say from the start what happens when you stop.
Interactions
Delayed gastric emptying can change how other oral medicines are absorbed, which matters most for drugs with a narrow therapeutic window. Combined with insulin or a sulfonylurea, the risk of hypoglycaemia rises and those doses usually need reducing. Alcohol tolerance often changes. Tell your clinician about everything you take, including supplements.
Frequently asked questions
How soon will I notice anything?
Most people notice appetite changes within the first week or two, often before the scale moves. The dose steps up over roughly four months, and weight change accumulates through that period rather than arriving at the end.
Is the compounded version the same as the brand?
No. It contains the same active ingredient, but it is prepared by a compounding pharmacy rather than manufactured as an FDA-approved product, and it has not been through FDA review for safety, effectiveness or manufacturing quality. It also contains added ingredients. Anyone who tells you they are identical is wrong.
What happens if I stop?
Weight regain after discontinuation is common and well documented. That is not a reason to avoid treatment, but any plan that does not address it is only half a plan. Your clinician and coach should discuss whether you stay on, taper, or replace it — ideally before you start.
Will I lose muscle?
Some, unless it is actively managed. Protein intake and resistance training are the countermeasures, and they are a large part of what your monthly coaching call is for. Lean mass is what protects your metabolism and your independence later.
Can I take it if I might become pregnant?
No. It is contraindicated in pregnancy and should be stopped well before trying to conceive. Raise this at intake rather than later.
References
- FDA — Compounding and the FDA: Questions and Answers — published Feb 1, 2023; accessed Sep 2, 2026
- WEGOVY (semaglutide) injection — FDA prescribing information — published Jun 4, 2021; accessed Sep 2, 2026
- Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med 2021;384:989-1002 — published Mar 18, 2021; accessed Sep 2, 2026
- FDA — Compounding and the FDA: Questions and Answers — published Feb 1, 2023; accessed Sep 2, 2026
- USP General Chapter <797> Pharmaceutical Compounding — Sterile Preparations — published Nov 1, 2023; accessed Sep 2, 2026
Ready when you are.
Check another state or optionBrowse freely. To purchase medication, you’ll enroll in membership and complete a clinician review. Medication is charged separately and is prescribed only when clinically appropriate.
Compounded by a licensed 503A pharmacy. This is NOT an FDA-approved finished product: compounded preparations are not reviewed by the FDA for safety, effectiveness or manufacturing quality, and it is not interchangeable with the brand-name product. It also contains added ingredients not present in the approved formulation.
Chronic weight management is an FDA-approved indication for this active ingredient. The indication is approved; this compounded formulation is not itself an approved product.